Saying certain things into the microphone can cure your Pokemon of various statuses. For instance, cure Sleep by saying "Wake up!" a few times and Confusion by saying "Snap!".
Original Pokemon games easter egg:Enter the entrance-building on the right of Canalave and talk to the police officer there. He will say: "Boy, I sure am thirsty...", which is a reference to Pokemon Red, Blue, and Yellow in which a police officer in a similar building will not let you through until you get him a drink.