If you have a first place team and you know its going to be very late in the draft, trade with a last place team. Occasionally you can even get a first and second round pick for just your first. This is a very good way to get young players on your already good team.
Get any player or draft pick you want during franchise mode. After the regular season, such as during the playoffs or immediately before the Superbowl, go to create a player and make a quarterback. Make him 45 years old so that he will quickly retire when the season is over. Next, make him a 99 overall. Sign him from the free agency and trade him for any player or draft pick that you desire. You can do this as many times as you need, and can get ten first round picks and every player desired.