-On the Asylum level, the key is to destroy all of Dr. Killjoy's movie projectors. After you destroy all the movie projectors, you will be able to open doors and eventually get out of the building. If you cannot destroy the projectors, find a way to block the projection. You will see these movie projectors towards the end of the game again. When you get into a room to battle Dr. Killjoy, destroy the projectors. There is one on the second floor that you cannot destroy. One will be in a crate hanging above. Find the rope end and cut it to destroy the projector. Turn the switch on next to the center table and stand underneath the contraption hanging above. Get zapped and then throw a fireball at the monster Torgue that is chained on the wall. The wall will explode, allowing you to exit the level.
-To defeat Dr. Killjoy in the Asylum level, you have to shoot all the projectors, which can be done easily by standing on the surgical table without harm to you, since Dr. Killjoy brings the Slayers back to life anyway. There is one camera in a cage above; shoot the rope holder on the wall to destroy the camera. Another difficult one is on the second floor. It can be destroyed by shooting the fuse box below it on the wall.