Complete the prologue and begin the first level. Enter the warehouse and search for cardboard boxes marked with "Sarif Industries" to find a QR barcode. Scan it on a QR readable phone to view a fictional website from the storyline.
Use the following answers to the conversations to unlock the best ending for that person:
Zeke Sanders Empathize, Empathize, Empathize, Empathize. Zeke will release the hostage and flee. If you let Zeke leave but make a mistake in the rest of the conversation, he will still go but the hostage will die.
Wayne Haas Absolve, Absolve, Absolve/Plead, Crush. This givesyou unrestricted access to the non-restricted areas of the Detroit police station. Note: This unlocks the "Desk Job" trophy.
David Sarif Refocus, Refocus, Refocus, Defend. David will give you emails and records about Adam's past and the security loophole. Note: This unlocks the "Yes Boss" trophy.
Tong Si Hung Pinpoint, Advise, Pinpoint. Adam can go downstairs to meet with the Triad leader that owns The Hive. Note: This unlocks the "Darker Shades" trophy.
Bill Taggart Confront, Discredit, Confront, Discredit. Bill Taggart gives you the location of Dr. Isaias Sandoval. Note: This unlocks the "Throwdown" trophy. Doctor Isaias Sandoval Tough Love, Empathize, Empathize. This prevents Isaias Sandoval from killing themself. Note: This unlocks the "Last Straw" trophy.
Hugh Darrow Extrapolate, Extrapolate, Appeal, Extrapolate/Appeal. Hugh Darrow deactivates the security system and you will get the code to shut down the Hyron system. Note: This unlocks the "Final Countdown" trophy.
-When hacking, save the game and hack the optional nodes-- but do not complete the hack. After hacking the nodes, load the previous saved game. Repeat the process. When you finally complete the hack, you will get all the nodes (from the previous times you loaded) along with the nodes you get normally. Use this on the computer in Jensen's office for 500 experience points every time you load for easy Praxis points.
-Hack everything you can if you have the required Hacking skill. This will result in easy experience points as well as possible access codes and credits.
-Non-lethal takedowns and kills earn more experience points than the lethal variety. Note: If you have the Reflex Booster Augmentation, you can will earn 125 experience points from a non-lethal takedown.
-In Hengsha, China every store has a back door. Open it and walk inside for a Traveler bonus of 100 experience points.
In the list of usernames and passwords for the police station first floor computers located in one of the pocketboys, there is one listed as: user "rdeckert", password "unicorn". This is a reference to the main character from Blade Runner and the unicorn from the visions in the film.
Upgrade Hacking and Strength and you can pick up turrets, which have unlimited ammo. Set them down or let them fire while you move to clear out a room easily! You still earn experience, including headshots. This can also be done with robots.
When waiting for the Funicular to come up in Picus Communications, enemies will appear. Before pressing the elevator button, save the game. Use heavy objects to block both entrances into the room. Note: This requires the Move/Lift Heavy Objects Augment. You can use the two vending machines outside the room, two crates next to the security computer, and the turret in the middle to block the lower doorway and the side corridor. If done correctly, the guards will stay outside while you are waiting for the Funicular.
Reach Hengsha; it is on the first mission upon your arrival. When you get to the hacker's apartment, look underneath the desk or above the computer in the left corner to see the "Forever Alone" meme on a Post-It note.
Enter the men's restroom at The Hive and find a pocket secretary that gives the door code for the back room. It also states that someone broke the first rule by talking about what goes on in the basement and is signed "T".
If you prefer to eliminate enemies quietly but are be finding it difficult, find an indestructible object such as a barrel or container and take it with you. When you find several enemies, stand in a position where you want an enemy to approach. While holding the barrel, throw it next to yourself or close to where you wish your target to approach. The entire group will be alerted upon hearing the object slam to the ground or wall you threw it at, but will only approach to investigate. The enemy will walk to the area alerted, stand where the sound came from, then start walking back after finding nothing. You can now knock them out or kill them undetected at your desired location. Note: If you throw the object a long distance, the investigating enemy may track the object's flight path directly back to your position. It is better to throw it nearby for repeated use.
One of the computers in the Singapore secret facility contains an email that mentions a stapler. The person's name is "Dwayne" (instead of Dwight) and mentions setting up a hidden camera to catch someone. The bottom of the messages reads "I know you have it Jim."