Perform the following steps to easily defeat the final boss:
Use Empower to get through his shield. Then use the Panzer Rocket Launcher and the Veil Blue Rocket Launcher.
Use Slow Motion or Empower.
Instead of running up the ramp, snipe him with a sniper rifle orrocket launcher. When you are about to climb the stairs, have a weaponequipped to kill the 4 legged sniffers. Then shoot him until he falls.
He will now have no power ups. Continue to shoot him and use explosives to kill him.