After locating the Gerudo Mesa and Cave of Ordeals in the Gerudo desert, you are able to unlock fairies and later Great Fairies at each spring around Hyrule.
While smaller fairies can be bottled, restore 8 hearts when used, or when you run out of hearts, the Great Fairies will give you a bottle full of "Great Fairy Tears". These heal your hearts completely and temporarily boosts your attack. However, you can only hold one bottle of this liquid at any time. Complete the corresponding amounts of rooms in Cave of Ordeals to unlock the following Fairies: