On the mission where you infiltrate the White Box company, after killing the guard by the front car lot, infiltrate the building. When you first see the room, either climb up the pipe and throw an object (frag grenade, proximity mine, remote mine, sticky cam, or EMP grenade) into the room. Even under the Realistic difficulty setting, the most the AI can do is shout and raise their guns, provided you have upgraded each gadget to the maximum. This room has many ways to get and complete any challenge, except for most of the Splinter Cell challenge group. Also, this can be repeated by reverting to last checkpoint an unlimited amount of times.